In the lab, 22 million immune cells map gene circuits
Gladstone, UCSF and Stanford switched off nearly 12,800 genes in human T cells from blood donors.
Diagnosi, protesi, vaccini, genomica: la medicina che guadagna anni di vita.
La medicina che guadagna anni di vita: screening assistiti dall’IA che esaminano milioni di pazienti, vaccini di nuova generazione, una genomica che passa dal sequenziamento alla terapia, protesi e impianti che restituiscono capacità perdute. La rubrica segue le sperimentazioni cliniche concluse, le autorizzazioni all’immissione in commercio, le adozioni ospedaliere — il momento in cui una tecnologia smette di essere una pubblicazione per diventare una cura.
I numeri comandano: coorti, tassi di rilevamento, mortalità evitata, costi. Copriamo volentieri i sistemi sanitari che adottano su larga scala — l’India, il Brasile, il Sud-est asiatico — perché le tecnologie frugali si mettono spesso alla prova lì prima di arrivare altrove. Ogni articolo si appoggia alla sperimentazione, all’autorizzazione o allo studio che lo fonda, e li cita.
Gladstone, UCSF and Stanford switched off nearly 12,800 genes in human T cells from blood donors.
The FGF21–IGFBP1 signal was identified in laboratory and mouse studies.
The analysis covered 1,276 adults treated at 36 U.S. hospitals between 2014 and 2023.
Full pivotal data show aficamten improved patients’ symptoms and exercise capacity in nHCM.
The three-week NTNU study followed 51 participants and measured steps, game data, interviews and questionnaires.
Penn researchers found that SGLT2 inhibitors directly activate PANK1 in human heart cells.
Six people with treatment-refractory disease received the therapy at Charité in Berlin.
The CIMH studied people with alcohol dependence and adolescents receiving psychiatric treatment.
The injectable system held iodine-131 inside patient-derived keloid tissue for up to 14 days.
More than 36,000 matched adults were studied in each vaccine group in the U.S. comparison.
The model used five early clinical variables to estimate conversion within one year.
The grafts survived at least 81 days, formed blood vessels and flexed continuously without external stimulation.
KRIBB researchers modeled a patient-linked SPAST deletion in human brain organoids.
The map covers 100 high-confidence autism risk genes and finds that 87% of interactions were previously unknown.
FRACTURE-ML used Swedish records from 3,542,647 people aged 50 and older, followed for up to 10 years.
ASM4 neurons helped suppress aggression in grouped male and female fruit flies.
About 50% on keto no longer met prediabetes criteria, versus 29% on Mediterranean and 7% on plant-forward diets.
UCLA researchers studied 14,655 patient-drug pairs using three major cancer biologics.